商品编号


CY-1184



品牌


MBL(CycLex & CircuLex)



公司


MBL Inc



公司分类


NAD+ biogenesis Assay Kits



Size

96 Assay

商品信息



Components

Non-coated Microplate, Antibody-coated Microplate, 10X Wash Buffer, Kinase Buffer, 20X ATP, 20X DTT, 10X GST-eIF2α Substrate, EDTA Solution, HRP conjugated Detection Antibody, Substrate Reagent, Stop Solution



Intended use

This kit is primarily designed to measure the activities of purified RNA-dependent protein kinase (PKR) or recombinant PKR for the rapid and sensitive evaluation of inhibitors or activators.



Storage temp.

4°C

Manufacturer

MBL



Citations

Stack EC
et al
. A novel role for calcium/calmodulin kinase II within the brainstem pedunculopontine tegmentum for the regulation of wakefulness and rapid eye movement sleep. J Neu
Roche
m. 112, 271-81 (2010)(PMID:19860859)
Yang YJ
et al
. Effects of scoparone on dopamine release in PC12 cells. Fitoterapia, 81, 497-502 (2010)(PMID:20080157)
Bodhinathan K

et al
.
Intracellular Redox State Alters NMDA Receptor Response during Aging through Ca2+/Calmodulin-Dependent Protein Kinase II. J Neurosci. 30, 1914-1924 (2010)(PMID:20130200)
Shahin R, Taha MO. Elaborate Ligand-Based Modeling and Subsequent Synthetic Exploration Unveil New Nanomolar Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitory Leads. Bioorg Med Chem. 20, 377-400 (2011)(PMID:22112539)
Ma CH
et al
.
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes. Redox Biol. 14, 72-81 (2017)(PMID:28869834)



Product category

Research area
Drug discovery
Signal transduction