商品编号


40322



品牌


Bpsbioscience



公司


BPS Bioscience Inc.



公司分类


Kinase(s)



Size

96 reactions

商品信息













Description:
The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, le
ADI
ng to the development of anticancer therapeutics targeting EGFR. EGFR(T790M/L858R) is an EGFR activating and drug resistance mutant that can be found in non-small-cell lung cancer cells. The EGFR(T790M/L858R) Kinase Assay Kit is designed to measure EGFR (T790M/L858R) Kinase activity for screening and profiling applications using Kinase-Glo? MAX as a detection reagent. The EGFR (T790M/L858R) Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant EGFR(T790M/L858R) enzyme, EGFR substrate, ATP and kinase assay buffer for 100 enzyme reactions.




Synonym(s):
EGFR, ErbB-1, HER1




Format:






Application(s):
Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.




Reference(s):
Nakamura, J.L. Expert Opin. Ther. Targets 11(4):463-472 (2007)




Scientific Category:
Kinase




Product Type:
Assay Kit




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