商品编号


79256



品牌


Bpsbioscience



公司


BPS Bioscience Inc.



公司分类


Ubiquitination



Size

96 reactions

商品信息





Species: 96 rxns









Background:
Deubiquitinases (DUBs) play important roles in pathways that are dysregulated in cancer, such as DNA repair, cell growth, and apoptosis. This makes DUBs attractive potential drug targets for many cancers and neurodegenerative diseases. Ubiquitin-specific-processing proteases (
USP
s) are the largest class of DUBs.
USP
7, also known as herpesvirus-associated ubiquitin-specific protease (HA
USP
), acts as a tumor suppressor by st
ABI
lizing p53 tumor suppressor as well as a regulator of gene expression in herpes simplex virus (HSV) and Epstein-Barr virus (EBV) infections.




Description:
The
USP
7 Inhibitor Screening Assay Kit is designed to measure
USP
7 activity for screening and profiling applications. The
USP
7 Inhibitor Screening Assay Kit comes in a convenient format, with a 96-well plate, fluorogenic, ubiquitinated substrate, assay buffer, and purified
USP
7 enzyme for 96 enzyme reactions.
USP
7 is incubated with a sample containing assay buffer and Ub-AMC Substrate, and then the plate is read, measuring fluorescence using a fluorescence reader.




UniProt
Q93009




Synonym(s):
Ubiquitin specific peptidase 7,
USP
7, HA
USP
,
USP
-7




Supplied As:
The
USP
7 Inhibitor Screening Assay Kit comes in a convenient format, with a 96-well plate, fluorogenic, ubiquitinated substrate, assay buffer, and purified
USP
7 enzyme for 96 enzyme reactions.




Contraindications:
DMSO >1%, strong acids or bases, ionic detergents, high salt




Format:





Instructions for use:
See assay kit data sheet for detailed protocol.




Storage / St
ABI
lity:
Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.




Application(s):
Great for studying enzyme kinetics and HTS applications.




Reference(s):
1. Pfoh, R., et al. Deubiquitinases and the new therapeutic opportunities offered to cancer. Endocrine-Related Cancer. 2015;22(1):T35-T54.




Warning(s):
Avoid freeze/thaw cycles.




Scientific Category:
Deubiquitinase




Product Type:
Assay Kit




Data shown is lot-specific.
Contact us
for specific information on other lots.