商品编号


60484



品牌


Bpsbioscience



公司


BPS Bioscience Inc.



公司分类


New Products



Size

2 vials

商品信息













Background:
The TLR family plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 is an endosomal receptor that recognizes single stranded RNA (ssRNA), and can recognize ssRNA viruses such as Influenza, HIV and HCV. TLR8 binding to the viral RNA recruits MyD88 and leads to activation of the transcription factor NF-κB and an antiviral response. Human TLR8 is functional but murine TLR8 is non-functional because it lacks five amino acids.




Description:
Recombinant HEK293 cell expressing firefly luciferase gene under the control of NF?B response elements with constitutive expression of human TLR8 (Toll-like receptor 8, also known as CD288, a member of the toll-like receptor (TLR) family (GenBank Accession No. NM_138636).




Synonym(s):
CD288, TLR8, Toll-like receptor 8, tlr, tlr-8 TLR, nfkb, nf-kb reporter TLR




Supplied As:
Each vial contains 2 x 106 cells in 1 ml of 10% DMSO




Mycoplasma Testing:
The cell line has been screened using the PCR-based Venor?GeM Mycoplasma Detection kit (
Sigma-Aldrich
, #MP0025) to confirm the absence of Mycoplasma species.




Instructions for use:
see data sheet for detailed culturing and assay protocol




Storage / St
ABI
lity:
Immediately upon receipt, store vials in liquid nitrogen.




Application(s):
? Screen for activators or inhibitors of TLR8 signaling in a cellular context ? Characterize the
BIOLOG
ical activity of TLR8 and its interactions with ligands




Notes:


Contact us for pricing.

License Disclosure:
?Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit the use of this cell line in humans or for therapeutic or drug use. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. Publications using this cell line should reference BPS Bioscience, Inc., San Diego.





Warning(s):
Avoid freeze/thaw cycles.




Scientific Category:
Immunotherapy




Product Type:
Cell Line




Data shown is lot-specific.
Contact us
for specific information on other lots.