商品编号


SYN-1070-M005



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

5 mg


商品信息


More Information



Product Details



Synonyms

NG95



Product Type

Chemical



Properties



Formula

C
20
H
25
ClN
6
O
3




MW

432.9



CAS

212844-54-7



Purity Chemicals

≥95%



Appearance

Solid.



Solubility

Soluble in DMSO or ethanol.



Declaration

Manufactured by SynKinase.



Other Product Data

Target: CDK2 - CDK7 - CDK5 - CDK4 | Kinase Group: CMGC | Substrate: Serine-Threonine
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



InChi Key

ZKDXRFMOHZVXSG-HNNXBMFYSA-N



Shipping and Handling



Shipping

AMBIENT



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 2 years after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Purvalanol B is a cyclin-dependent kinase inhibitor with IC(50) values of 6, 6, 9, > 10,000, and 6nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35, respectively. Purvalanol B has also been shown to have anti-proliferative properties, mediated by p42/p44 MAPK.


Product References

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors: N.S. Gray, et al.; Science
281,
533 (1998)

ATP-site directed inhibitors of cyclin-dependent kinases: N. Gray, et al.; Curr. Med. Chem.
6,
859 (1999)

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol: M. Knockaert, et al.; Oncogene
21,
6413 (2002)