商品编号


CDX-P0063-M005



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

5 mg

商品信息


More Information



Product Details



Synonyms

NCH 51; Cpd 51; S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate



Product Type

Chemical



Properties



Formula

C
20
H
26
N
2
O
2
S
2




MW

390.56



CAS

848354-66-5



Source/Host Chemicals

Synthetic.



Purity Chemicals

≥95% (HPLC)



Appearance

White crystals.



Solubility

Soluble in DMSO (25mg/ml).



Identity

Determined by NMR.



Declaration

Manufactured by Chemodex.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



InChi Key

MDYDGUOQFUQOGE-UHFFFAOYSA-N



Shipping and Handling



Shipping

AMBIENT



Short Term Storage

+4°C



Long Term Storage

+4°C



Handling Advice

Keep cool and dry.
Protect from light and moisture.



Use/St
ABI
lity

Stable for at least 2 years after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Non-hydroxamate HDAC inhibitor (HDACi) (IC50: 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively). Cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1μM). Also reactivates latent HIV-1 gene expression.


Product References
(1) T. Suzuki, et al.; J. Med. Chem. 48, 1019 (2005) | (2) T. Sanda, et al.; Leukemia 21, 2344 (2007) | (3) T. Suzuki, et al.; Bioorg. Med. Chem. Lett. 17, 1558 (2007) | (4) A.F. Victoriano, et al.; FEBS Lett. 585, 1103 (2011)