商品编号


AG-40B-0157-3010



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

Collagen Triple Helix Repeat-containing Protein 1; NMTC1



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

Human CTHRC1 (aa 31-243) is fused at the N-terminus to a FLAG
?
-tag.



Crossreactivity

Human



MW

~Two bands of 25-30 kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link Q96CG8: CTHRC1 (human)
FLAG is a registered trademark of
Sigma-Aldrich
Co.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Collagen triple helix repeat containing-1 (CTHRC1) is a 30kDa glycosylated secretory protein containing a short collagen-like motif contributing to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. CTHRC1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells, in the hypothalamus, pituitary gland and remodeling tissues. Aberrant expression of CTHRC1 is present in human solid cancers and likely to be associated with cancer invasion and metastasis. With
ADI
ponectin and other members of the C1q/TNF-related protein (
Ctrp
) family, CTHRC1 shares the presence of a short N-terminal collagen domain but it lacks the characteristic C1q domain that defines the
Ctrp
family of proteins. A recent study identifies CTHRC1 as a novel circulating hormone with metabolic effects.