商品编号


AG-40B-0083-3050



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

3 x 50 ?g


商品信息


More Information



Product Details



Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 5; TNFRSF5; CD40L Receptor



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193).



Crossreactivity

Human
Mouse



Specificity

Binds human and mouse CD40L.



BIOLOG
ical Activity

Blocks the binding of CD40L to CD40.



MW

~54kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

1mg/ml after reconstitution.



Reconstitution

Reconstitute with 50μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link P25942: CD40 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After receipt, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


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CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-β-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.