商品编号


CHI-HF-210CD40-C100



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 5; TNFRSF5; CD40L Receptor



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

The extracellular domain of human CD40 (aa 21-193) is fused to the N-terminus of the Fc region of human IgG1.



Crossreactivity

Human



BIOLOG
ical Activity

Measured by its binding
ABI
lity in a functional
ELISA
assay.



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" protein="" (lal="" test;="" lonza).="">0.06eu>



Reconstitution

Reconstitute with 100 ?l sterile water.
Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI reference AAH12419.1: CD40 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





CD40 [TNFRSF5] is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-κB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (adapter proteins) have been identified to serve as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-β-induced microglial activation and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by the in
ABI
lity of B cells to undergo isotype switching, as well as an in
ABI
lity to mount an antibody-specific immune response and a lack of germinal center formation.