商品编号


CHI-HF-211CD38-C100



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; ADPRC 1; T10



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of human CD38 (aa 43 - 300) is fused to the N-terminus of the Fc region of mouse IgG2a.



Crossreactivity

Human



MW

~70kDa (SDS-PAGE)



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<5eu g="" protein="" (lal="" test;="" lonza).="">5eu>



Reconstitution

Reconstitute with 100 ?l sterile water. Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI reference P28907: CD38 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia poss
IBL
y related to autism. The CD38 protein is a
Marker
of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.