商品编号


1567/1



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

1 mg

商品信息

Description:
Bacterial RNA polymerase inhibitor

Chemical Name:

N
-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-
b
]pyrrol-6-yl)acetamide

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC
50
= 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.



Technical Data



M. Wt

228.28



Formula

C
8
H
8
N
2
O
2
S
2




Storage

Desiccate at -20°C



Purity

≥98% (HPLC)



CAS Number

87-11-6



PubChem ID

6870



InChI Key

MHMRAFONCSQAIA-UHFFFAOYSA-N



Smiles

O=C(N2C)C(NC(C)=O)=C1C2=CSS1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

5

22





Preparing Stock Solutions

The following data is based on the
product
molecular weight
228.28
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

4.38 mL

21.9 mL

43.81 mL



5 mM

0.88 mL

4.38 mL

8.76 mL



10 mM

0.44 mL

2.19 mL

4.38 mL



50 mM

0.09 mL

0.44 mL

0.88 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Jimenez

et al
(1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in
Saccharomyces cerevisiae
. Antimicrob.Agents Chemother.
3
729 PMID: 4597739


Minamiguchi

et al
(2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer
93
307 PMID: 11433393


O'Neill

et al
(2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of
Staphylococcus aureus
. Antimicrob.Agents Chemother.
44
3163 PMID: 11036042




Keywords: Thiolutin, supplier, Bacterial, RNA, polymerases, inhibitors, inhibits, Antibiotics, vitronectin, cell, Adhesion, Molecules, cam, Cell, Adhesion, Molecules, RNA/DNA, Polymerase, Antibiotics, RNA, Polymerase, RNA/DNA, Polymerase,
Tocris
Bioscience