商品编号


1489/1



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

1 mg

商品信息

Description:
Inhibitor of DNA and RNA polymerase

Chemical Name:
(1
S
)-5-Deoxy-1-C-[(2
S
,3
S
)-7-[[2,6-dideoxy-3-
O
-(2,6-dideoxy-
β
-
D
-ar
ABI
no-hexopyranosyl)-
β
-
D
-ar
ABI
no-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-
β
-
D
-ribo-hexopyranosyl-(1.fwdarw.3)-
O
-2,6-dideoxy-
β
-
D
-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-
β
-
D
-ar
ABI
no-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-
O
-methyl-
D
-
threo
-2-pentulose

Purity:
≥95% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg
2+
or Zn
2+
, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.



Technical Data



M. Wt

1085.16



Formula

C
52
H
76
O
24




Storage

Desiccate at -20°C



Purity

≥95% (HPLC)



CAS Number

18378-89-7



PubChem ID

90479798



InChI Key

CFCUWKMKBJTWLW-YZCDWGPJSA-N



Smiles

OC1=C2C(C=C3C(C([C@@H](OC5OC(C)C(O)C(OC6OC(C)C(O)C(OC7OC(C)C(O)C(O)(C)C7)C6)C5)[C@@]([C@H](OC)C([C@@H](O)[C@H](O)C)=O)([H])C3)=O)=C2O)=CC(O[C@@H]4OC(C)C(O)C(OC8OC(C)C(O)C(O)C8)C4)=C1C



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

54.26

50





Preparing Stock Solutions

The following data is based on the
product
molecular weight
1085.16
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

0.92 mL

4.61 mL

9.22 mL



5 mM

0.18 mL

0.92 mL

1.84 mL



10 mM

0.09 mL

0.46 mL

0.92 mL



50 mM

0.02 mL

0.09 mL

0.18 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Demicheli and Garnier-Suillerot
(1991) Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg
2+
ion. Biochem.Biophys.Res.Commun.
177
511 PMID: 1828342


Miller

et al
(1987) Mithramycin selectively inhibits transcription of G-C containing DNA. Am.J.Med.Sci.
294
388 PMID: 2962490


Ray

et al
(1990) Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene. Am.J.Med.Sci.
300
203 PMID: 2147360




Keywords: Mithramycin A, supplier, inhibitors, inhibits, DNA, RNA, polymerases, MithramycinA, antibiotics, DNA,, RNA, and, Protein, Synthesis, RNA/DNA, Polymerase, Antibiotics, RNA, Polymerase, RNA/DNA, Polymerase,
Tocris
Bioscience