商品编号


4514/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

50 mg

商品信息

Description:
Tankyrase inhibitor

Chemical Name:

N
-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2
H
-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in st
ABI
lization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells
in vitro
.



External Portal Information

Chemicalprobes.org
is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of JW55 is reviewed on the chemical probes website.



Compound Libraries

JW 55 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

434.48



Formula

C
25
H
26
N
2
O
5




Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

664993-53-7



PubChem ID

2946601



InChI Key

ZJZWZIXSGNFWQQ-UHFFFAOYSA-N



Smiles

O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

43.45

100



ethanol

43.45

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
434.48
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.3 mL

11.51 mL

23.02 mL



5 mM

0.46 mL

2.3 mL

4.6 mL



10 mM

0.23 mL

1.15 mL

2.3 mL



50 mM

0.05 mL

0.23 mL

0.46 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Waaler

et al
(2012) A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res.
72
2822 PMID: 22440753




Keywords: JW 55, supplier, JW55, wnt, signaling, inhibitors, inhibits, tankyrase, tnks1/2, tnks1, tnks2, beta-catenin, β-catenin, b-catenin, Poly(ADP-ribose), Polymerase, Tankyrase, Tankyrase,
Tocris
Bioscience