商品编号


F7140



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki ~ 0.5 nM, 1 nM and 1 nM in cell-free assays. ABT-263 blocks the Bcl-2/Bcl-xL interactions, thereby promoting apoptosis.


Additional Information






Product Name:

ABT-263 (Navitoclax)



Also Known As:

4-?[4-?[[2-?(4-?chlorophenyl)?-?5,?5-?dimethyl-?1-?cyclohexen-?1-?yl]?methyl]?-?1-?piperazinyl]?-?N-?[[4-?[[(1R)?-?3-?(4-?morpholinyl)?-?1-?[(phenylthio)?methyl]?propyl]?amino]?-?3-?[(trifluoromethyl)?sulfonyl]?phenyl]?sulfonyl]?-benzamide



Catalog No.:

F7140



Size:

5 mg



CAS:

N/A



Formula:

C
47
H
55
ClF
3
O
6
S
3



Molecular Weight:

974.61 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Tse C,
et al
. (2008) Cancer Res. 68(9), 3421-3428.




Details

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki ~ 0.5 nM, 1 nM and 1 nM in cell-free assays. ABT-263 blocks the Bcl-2/Bcl-xL interactions, thereby promoting apoptosis.

Solubility:

> 20 mg/ml in DMSO

Working Condition:

1 μM in cell culture assay