商品编号


F7131



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

25 mg

商品信息

PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.


Additional Information






Product Name:

PAC-1



Also Known As:

N/A



Catalog No.:

F7131



Size:

25 mg



CAS:

315183-21-2



Formula:

C
23
H
28
N
4
O
2



Molecular Weight:

392.49 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at 2-8°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. Putt
et al
. (2006) Nat.Chem.Biol. 2 543.
2. Peterson
et al
. (2009) J.Med.Chem. 52 5721.




Details

PAC-1 is a caspase-3 activator. It promotes cleavage of procaspase-3 to produce caspase-3 (EC50 = 0.33 μM). It also converts procaspase-7 to caspase-7 at higher dose (EC50 = 4.5 μM). By induction of caspase-3 and 7, PAC-1 can induce apoptosis in both cancerous cells and non-cancerous cells, but more efficiently for cancerous cells.