商品编号


F7101



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

50 mg


商品信息

Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF?-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.

Additional Information






Product Name:

Necrostatin-1



Also Known As:

No



Catalog No.:

F7101



Size:

50 mg



Molecular Weight:

259.33 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>98% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.



PDF Data Sheet:

Download PDF datasheet



NCBI RefSeq:

N/A



Image(s):

(Click image to enlarge)

Purity check of Necrostatin-1 by HPLC



Shipping Method:

Room temperature shipping



References:

Degterev A,
et al
. (2008) Nat Chem Biol. 4(5):313-21.




Details

Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF?-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.

Images
(Click image to enlarge)

Purity check of Necrostatin-1 by HPLC