商品编号


F6150



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), as well as other kinases including TANK-binding kinase 1 (TBK1), Aurora B and IkB kinase ε (IKKε). BX-795 prevents TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β.


Additional Information






Product Name:

BX795



Also Known As:

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide



Catalog No.:

F6150



Size:

5 mg



CAS:

702675-74-9



Formula:

C
23
H
26
IN
7
O
2
S



Molecular Weight:

591.47 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Feldman RI,
et al
. (2005) J.Biol.Chem. 280 19867.




Details

BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), as well as other kinases including TANK-binding kinase 1 (TBK1), Aurora B and IkB kinase ε (IKKε). BX-795 prevents TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β.

Solubility:

> 20 mg/ml in DMSO