商品编号


F6130



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

10 mg


商品信息

Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer,
ADI
pogen
esis, diabetes, tuberous sclerosis, and cardiovascular disease.


Additional Information






Product Name:

Rapamycin



Also Known As:

AY-22989, LCP-Siro, RAPA, Rapamune, Sirolimus, SILA 9268A



Catalog No.:

F6130



Size:

10 mg



Molecular Weight:

914.17 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>99% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

(Click image to enlarge)

Purity check of Rapamycin by HPLC



Shipping Method:

Room temperature shipping



References:

1. Corradetti MN,
et al
. (2006) Oncogene. 25(48):6347-60.
2. Foster KG,
et al
. (2010) J Biol Chem. 285(19):14071-7.
3. Malagelada C,
et al
. (2010) J Neurosci. 30(3):1166-75.




Details

Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer,
ADI
pogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.
Images
(Click image to enlarge)

Purity check of Rapamycin by HPLC