商品编号


YIF-LF-PA0155



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

VDAC; VDAC1; hVDAC1; VDAC-1; Porin 31HM; Porin 31HL; Plasmalemmal Porin; Outer Mitochondrial Membrane Protein Porin 1; Voltage-dependent Anion-selective Channel Protein 1



Product Type

Polyclonal Antibody



Properties



Immunogen/Antigen

Synthesis peptide (KLH coupled) corresponding to C-terminal residues of Human VDAC1.



Application

Western Blot (1:2,000)



Crossreactivity

Human
Mouse
Rat



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Voltage-dependent anion channel(VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC contitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity. Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the perme
ABI
lity transition pore complex (PTPC) respons
IBL
e for the release of mitochondrial products that triggers apoptosis.


Product References
1) Hinsch KD, et al.(2004) J. Biol. Chem. 279(15):15281-8. (General)
2) Liberatori S, et al.(2004) Proteomics, 4(5):1335-40. (General)
3) Alfons Lawen, et al.(2005) Int J Biochem Cell Biol. 37(2):277-82. (General)
4) Mark A. Baker, et al.(2004) J. Biol. Chem. 279(6):4811-4819. (General)