商品编号


YIF-LF-MA0229



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TNNI3; TNNC1; Cardiac Troponin I; Troponin I; Cardiac Muscle



Product Type

Monoclonal Antibody



Properties



Clone

3D10



Isotype

Mouse IgG2b κ



Immunogen/Antigen

Recombinant human His-Troponin I (partial) protein purified from E. coli.



Application


ELISA
Western Blot (1:2,000)
Immunoprecipitation (2 μl)



Crossreactivity

Human



Purity Detail

Ammonium sulfate precipitation.



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Troponin complex consists of three components, troponin I, T and C. The complex along with tropomyosin is located on the actin filament and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. Three isoforms of troponin I have been described for striated muscle. Two isoforms are characteristic for fast and slow skeletal fibers and one isoform for cardiac muscle. Troponin I consists of 181-211 amino acid residues, and the cardiac isoform is larger due to the presence of an additional N-terminal peptide which has a
BIOLOG
ically important function in the interactions of troponin I and troponin C. The main function of troponin I is the inhibition of actomyosin ATPase activity. Cardiac troponin I and T are sensitive bio
Marker
s of myocardial injury and have become central to the diagnosis of myocardial infarction. They are elevated in many clinical syndromes associated with direct myocardial injury, myocardial ischemia, or ventricular strain. They are also released in a number of clinical situations in which thrombotic complications of coronary artery disease. These situations include conditions like pulmonary embolism, sepsis, myocarditis, and acute stroke. Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.


Product References
1) Fromm RE Jr et al., (2007) Crit Care Med. 35(2):584-588. (General)
2) Babuin L and Jaffe AS, (2005) CMAJ. 173(10):1191-1202. (General)
3) Hunkeler NM et al., (1991) Circ. Res. 69;1409-1414. (General)