商品编号


YIF-LF-MA0174



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TTR; ATTR; PALB; TBPA; Prealbumin; Transthyretin



Product Type

Monoclonal Antibody



Properties



Clone

10E1



Isotype

Mouse IgG2a κ



Immunogen/Antigen

Recombinant human protein purified from E. coli .



Application

Western Blot (1:2,000)
Immunoprecipitation (3 μl)



Crossreactivity

Human



Purity Detail

Ammonium sulfate precipitation.



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Transthyretin (TTR, 55 kDa homotetramer) is a thyroid hormone-binding protein that transports thyroxine (T4) from the bloodstream to the brain. TTR was originally called prealbumin because it ran faster than albumin on electrophoresis gels. TTR is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine. TTR is suggested that plays an essential role in brain function. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.


Product References
1) Palha JA. Clin Chem Lab Med. (2002) vol.40(12): pp.1292-300. (General)
2) Hamilton JA, Benson MD. Cell Mol Life Sci. (2001) vol.58(10): pp.1491-521. (General)
3) Hund E, et al, Neurology. (2001) vol.56(4): pp.431-5. (General)