商品编号


YIF-LF-PA0117



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TGC; TGM2; TG(C); TGase H; TGase-2; TGase C; EC=2.3.2.13; Transglutaminase-2; Transglutaminase H; Transglutaminase C; Tissue transglutaminase; Protein-Glutamine γ-Glutamyltransferase 2



Product Type

Polyclonal Antibody



Properties



Immunogen/Antigen

Recombinant human protein purified from E. coli.



Application

Western Blot (1:2,000)
Immunoprecipitation (1 μl)



Crossreactivity

Human



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Transglutaminase (TGase) catalyses the crosslink of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core and two C-terminal β-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer’s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Aβ peptide, β-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.


Product References
1) Griffin, M. et al. (2002) Biochem. J. 368, 377-396. (General)
2) Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. (General)
3) Kim, SY. et al. (2002) Neu
Roche
m. Int. 40, 85-103. (General)