商品编号


AG-20T-0301-C100



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Toll-like Receptor 3; CD283



Product Type

Monoclonal Antibody



Properties



Clone

ABM15D5



Isotype

Mouse IgG1κ



Immunogen/Antigen

Recombinant human TLR3 protein (aa 25-370).



Application


Flow Cytometry:
(2μg/10
6
cells)
Western Blot:
(2-4μg/ml)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human



Specificity

Recognizes human TLR3.



Purity

Protein G purified.



Concentration

0.5mg/ml



Formulation

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.



Accession Number

O15455



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 consist of pathogen-binding ECDs (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.