商品编号


AG-20T-0300-C100



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Toll-like Receptor 2; CD282; Toll/Interleukin-1 Receptor-like Protein 4; TIL4



Product Type

Monoclonal Antibody



Properties



Clone

ABM3A87



Isotype

Mouse IgG1κ



Immunogen/Antigen

Recombinant human TLR2 protein (aa 180-420).



Application


Flow Cytometry:
(0.5μg/10
6
cells)
Immunohistochemistry:
(5μg/ml; paraffin sections)
Western Blot:
(2-4μg/ml)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human
Mouse



Specificity

Recognizes human and mouse TLR2.



Purity

Protein G purified.



Concentration

0.5mg/ml



Formulation

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TLR2 (Toll-like Receptor 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts via MYD88 and TRAF6, le
ADI
ng to NF-κB activation, cytokine secretion and the inflammatory response. TLR2 resides on the plasma membrane where it responds to lipid-containing pathogen-associated molecular patterns (PAMPs), such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipopeptides. It does this by forming dimeric complexes with either TLR1 or TLR6, which consequently is the initial step in a cascade of events le
ADI
ng to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infections with these pathogens. TLR2 also interacts with a large number of non-TLR molecules such as LY96 (MD-2), allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial and epithelial cells.