商品编号


JP28137



品牌


IBL



公司


IBL,inc



公司分类


Antibodies


商品信息

Quantity / Tests
50 ?g
Species / Antigen
human, mouse
Host
rabbit
Subclass / Clone
IgG
Type
Polyclonal
Purification
with Antigen Peptide
Label
No
Regulatory Status:
For research use only


Details for:


?
Anti-Human RIG-I (CTD) Rabbit IgG

This antibody was raised against the c-terminal domain of human RIG-I.

RIG-I (retinoic acid induc
IBL
e gene-I) is a cytoplasmic viral sensor, that has a RNA helicase domain and it is believed to recognize virus-derived double-stranded RNA (dsRNA). It is considered that RIG-I normally exists as an inactive form in the cytoplasm and turns to an active form when it recognizes dsRNA produced as a by-product of viral replication. It is thought that the active form of RIG-I exposes a signaling domain called CARD (caspase recruitment domain) which is normally hidden by steric hindrance. Downstream signaling then is activated by multimerization and interaction of CARD with IPS-1 expressed on mitochondria, eventually inducing the activation of interferon gene. Thus, RIG-I is believed to play an important role in viral infection-induced signaling.

This antibody recognizes CTD (C terminal domain) of RIG-I and is able to detect RIG-I localized in avSGs (antiviral stress granules) that are genesis-induced in virus-infected cells.

Distributed by
IBL
International

For concrete data please consult the Instruction for Use in the download box on the right side.