商品编号


AG-CP3-0006-3001



品牌


Adipogen



公司


Adipogen



公司分类


Cancer



Size

3 x 1 mg


商品信息


More Information



Product Details



Synonyms

Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone



Product Type

Chemical



Properties



Formula

C
26
H
25
F
2
N
3
O
6




MW

513.5



CAS

1135695-98-5 (anhydrous)



Source/Host Chemicals

Synthetic.



Purity Chemicals

≥95% (TLC)



Appearance

White solid.



Solubility

Soluble in DMSO.



BIOLOG
ical Activity

The IC
50
range for caspases -1, -3, -8, -9, -10, and -12 is 25-400 nM.



Other Product Data

Q-VD-OPh does not exhibit toxic effects at typical working concentrations: 10-20 μM for
in vitro
cell culture applications, 10-120 (up to 1000) mg/kg for
in vivo
animal studies. Q-VD-OPh is a small hydrophobic compound and requires DMSO for solubilization. Stock solutions as high as 200mg/ml have been prepared in DMSO. To retain solubility in water at concentrations above 1mg/ml, 80 % DMSO is suggested. For tissue culture studies 10mM or 20mM stock solutions are prepared in DMSO and diluted 1:1000 directly into the tissue culture medium. For
in vivo
studies Q-VD-OPh has been admi
NIST
ered in 80% to 100% DMSO to assure solubility at the doses given.
For Negative Control see Prod. No. AG-CP3-0007.



InChi Key

OOBJCYKITXPCNS-AKRCKQFNSA-N



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Keep cool and dry.



Use/St
ABI
lity

Stable for at least 3 years after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF






Cell permeable, irrevers
IBL
e and non-toxic non-FMK pan-caspase inhibitor with improved potency, st
ABI
lity and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group.

The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media.

Inhibits ICE-family protease/caspase processing, le
ADI
ng to apoptosis and autophagy induction.

Decreases proteasome activity.

Used in apoptosis and inflammasome studies.



Product References

Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis
8,
345 (2003)

Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: a role for gender: S. Renolleau, et al.; J. Neu
Roche
m.
100,
1062 (2007)

The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis
15,
1403 (2010)

The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res.
36,
884 (2012)