商品编号


6075



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

5 mg

商品信息

Description:
MDM2 antago
NIST
; active enantiomer of Nutlin-3 (Cat. No. 3984)

Chemical Name:
4-[[(4
S
,5
R
)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1
H
-imidazol-1-yl]carbonyl]-2-piperazinone

Purity:
≥97% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

MDM2 antago
NIST
(IC
50
= 90 nM); inhibits the MDM2-p53 interaction. Active enantiomer of Nutlin-3 (Cat. No. 3984). Induces expression for P53 regulated genes. Suppresses tumor growth
in vivo
>98% in prostate cancer and osteosarcoma cancer models. Antiproliferative.



Technical Data



M. Wt

581.49



Formula

C
30
H
30
Cl
2
N
4
O
4




Storage

Store at -20°C



Purity

≥97% (HPLC)



CAS Number

675576-98-4



PubChem ID

11433190



InChI Key


BD
UHCSBCVGXTJM-WUFINQPMSA-N



Smiles

ClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

58.15

100



ethanol

58.15

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
581.49
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

1.72 mL

8.6 mL

17.2 mL



5 mM

0.34 mL

1.72 mL

3.44 mL



10 mM

0.17 mL

0.86 mL

1.72 mL



50 mM

0.03 mL

0.17 mL

0.34 mL






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Reconstitution Calculator



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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Tovar

et al
(2006) Small-molecule MDM2 antago
NIST
s reveal aberrant p53 signaling in cancer: implications for therapy. Proc.Natl.Acad.Sci.USA.
103
1888 PMID: 16443686


Vassilev

et al
(2004)
In vivo
activation of the p53 pathway by small-molecule antago
NIST
s of MDM2. Science
303
844 PMID: 14704432




Keywords: Nutlin 3a, supplier, Nutlin3a, p53, activators, MDM2, antagonism, antago
NIST
s, p53-MDM2, activates, Ubiquitin, E3, Ligases,
Tocris
Bioscience