商品编号


5054



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

10 mg

商品信息

Description:
Selective PARP-3 inhibitor

Chemical Name:
3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1
S
)-1-phenylethyl]-2-quinazolinepropanamide

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of PARP-3 (IC
50
= 0.89
μ
M). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC
50
values are 6.3, 10.8 and >30
μ
M respectively). Enhances CRISPR-Cas9-mediated
HER2
mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.



Compound Libraries

ME 0328 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

321.37



Formula

C
19
H
19
N
3
O
2




Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

1445251-22-8



PubChem ID

71571526



InChI Key

QIHBWVVVRYYYRO-ZDUSSCGKSA-N



Smiles

O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

32.14

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
321.37
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.11 mL

15.56 mL

31.12 mL



5 mM

0.62 mL

3.11 mL

6.22 mL



10 mM

0.31 mL

1.56 mL

3.11 mL



50 mM

0.06 mL

0.31 mL

0.62 mL






Molarity Calculator






Molarity Calculator

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Reconstitution Calculator






Reconstitution Calculator



The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.



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ul



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Mass (in vial)




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ug
ng



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mg/ml
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ng/ml













Dilution Calculator






Dilution Calculator

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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Lindgren

et al
(2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol.
8
1698 PMID: 23742272


Wang and Sun
(2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. PMID: 27815036




Keywords: ME 0328, supplier, ME0328, PARP3, ARDT3, inhibitors, inhibits, selective, CRISPR-Cas9, HER2, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience