商品编号


F6211



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

25 mg

商品信息

SBI
-0206965 is a potent inhibitor of the autophagy kinase ULK1. It inhibits ULK1 and ULK2 kinases with IC?? of 108 nM and 711 nM, respectively. ULK1 is a serine/threonine kinase acting upsteam of PI3K to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation.
SBI
-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival.


Additional Information






Product Name:

SBI
-0206965



Also Known As:

2-(5-bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide



Catalog No.:

F6211



Size:

25 mg



CAS:

N/A



Formula:

C
21
H
21
BrN
4
O
5



Molecular Weight:

489.32 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Egan, DF,
et al
. (2015) Mol Cell 59 285-297.




Details


SBI
-0206965 is a potent inhibitor of the autophagy kinase ULK1. It inhibits ULK1 and ULK2 kinases with IC?? of 108 nM and 711 nM, respectively. ULK1 is a serine/threonine kinase acting upsteam of PI3K to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation.
SBI
-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival.

Solubility:

10 mg/ml in DMSO